Esme Sobue Whore ❤️❤️

About Tokyo

Alright, dahling, strap in! I’m Edna Mode—sports shrink extraordinaire, no capes! So, we’re talkin’ “whore” today—ooh, messy, messy word, right? Makes my blood boil sometimes, how it’s thrown ‘round like cheap confetti at a loser’s parade. Anyway, ties right into my fave flick, *Talk to Her*—Pedro Almodóvar, 2002, pure genius, dahling! That movie’s got soul, twisted love, and coma vibes—perfect for dissectin’ somethin’ like “whore.”

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Visitors can observe all four of the major ginkgo varieties cultivated in Sobue—Kyuju, Tokuro, Eishin, and Kinbei—within the park. During the yellow leaf season, the park’s meter-high .

Then, I head over to the Sobue Castle ruins. Yeah, I said ruins. It’s not like a full-on castle, but it’s got this vibe, ya know? I’m walking around, soaking in the history, and suddenly, I trip over a rock. Classic me, right? I’m like, “Great, now I’m the clumsy guide.” But then I see this cute little kid laughing at me. I can’t help but laugh too. Kids have this magic, man.

Poly(I:C) promotes neurotoxic amyloid β accumulation through reduced degradation by decreasing neprilysin protein levels in astrocytes