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Gregori et al. have shown that a specialized tolerogenic type of DCs is accumulating in the human decidua during pregnancy. These cells express HLA-G and are named DC-10 because they secrete high amounts of IL-10. DC-10 can induce type 1 regulatory T (Tr1) cells, which are characterized by their cytokine profile – secretion of IL-10 and TGF-β among others (73, 85). In mice, it has been shown that the overall CD4+CD25+ suppressive T cell pool increases during pregnancy, that a third of the CD4+CD25+ T cells in the pregnant uterus express FoxP3, and that depletion of CD25+ T cells results in gestation failure (88).Vauvert Whore
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