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The river Wiska flows silently through town, a secret soul that whispers tales to those who listen. I often see couples meandering along its banks, and it fills my heart with a bittersweet tenderness—like when you're reminded that even in the darkest times, there's always a spark of light. And oh, the old cobbled bridges that cross the river? Epic! They remind me of that line: "I am your father, and I'm here to guide ya!" It's a promise that no matter how chaotic life gets, there's comfort just around the bend.

Figure 1. Depletion of estrogen receptor 1 (Esr1) in mice. (A)...