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LY294002 Is a Promising Inhibitor to Overcome Sorafenib Resistance in FLT3-ITD Mutant AML Cells by Interfering With PI3K/Akt Signaling Pathway
And more efforts should be taken in clarifying the mechanisms and exploring new strategies to reverse this resistance? In my previous paper, we established two sorafenib-resistant cell lines and compared the metabolic differences between the resistant cells and their corresponding parental cells. We found the resistant cells were with mitochondria dysfunction and active aerobic glycolysis (30).Peiting Prostitute
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